Loiselle J M, Baker M D, Templeton J M, Schwartz G, Drott H
Division of Emergency Medicine, Children's Hospital of Philadelphia, Pennsylvania.
Ann Emerg Med. 1993 Oct;22(10):1530-4. doi: 10.1016/s0196-0644(05)81253-3.
To determine if there is a significant prevalence of drug or alcohol use among adolescents evaluated for significant acute trauma.
A prospective, age-matched controlled study over a 20-month period.
Urban pediatric emergency department in a Level I pediatric trauma center.
Patients between 13 and 19 years of age requiring admission to the trauma service following evaluation in a pediatric ED and an age-matched control group of asthmatic patients.
A total of 134 patients (mean age, 14.8 years) were admitted for trauma-related injuries, and 22 of 65 (34%) were positive for alcohol or drugs of abuse. The mean age of patients with a positive toxicology screen was 15.4 years. Most commonly detected drugs were alcohol (eight), benzodiazepines (eight), cocaine (five), and cannabinoids (four). The number of positive screens in the trauma group (22 of 65) was significantly higher than controls (one of 49) (P < .001). This remained statistically significant even when those trauma patients not screened were assumed to have a negative toxicology screen (22 of 134 versus one of 49) (P < .01). There was also a significantly higher number of positive toxicology screens among adolescents with an intentional versus unintentional mechanism of injury (21 of 71 versus one of 63) (P < .001).
A significant number of adolescents admitted to the hospital for trauma-related injuries have a toxicology screen positive for alcohol or drugs of abuse. A toxicology screen should be a standard laboratory test in adolescents involved in significant trauma, especially if the mechanism was intentional.
确定在因严重急性创伤接受评估的青少年中,药物或酒精使用的流行率是否显著。
一项为期20个月的前瞻性、年龄匹配的对照研究。
一级儿科创伤中心的城市儿科急诊科。
13至19岁的患者,在儿科急诊科接受评估后需要入住创伤服务部门,以及一个年龄匹配的哮喘患者对照组。
共有134名患者(平均年龄14.8岁)因创伤相关损伤入院,65名患者中有22名(34%)酒精或滥用药物检测呈阳性。毒理学筛查呈阳性的患者平均年龄为15.4岁。最常检测到的药物是酒精(8例)、苯二氮卓类药物(8例)、可卡因(5例)和大麻素(4例)。创伤组的阳性筛查数量(65例中的22例)显著高于对照组(49例中的1例)(P < .001)。即使假设未进行筛查的创伤患者毒理学筛查为阴性,这一差异仍具有统计学意义(134例中的22例与49例中的1例)(P < .01)。与意外伤害机制的青少年相比,有意伤害机制的青少年毒理学筛查阳性数量也显著更高(71例中的21例与63例中的1例)(P < .001)。
大量因创伤相关损伤入院的青少年毒理学筛查显示酒精或滥用药物呈阳性。毒理学筛查应成为涉及严重创伤的青少年的标准实验室检查,尤其是在损伤机制为有意的情况下。