Todorov T, Mechkov G, Vutova K, Georgiev P, Lazarova I, Tonchev Z, Nedelkov G
Institute of Pharmacology, Medical Academy, Sofia, Bulgaria.
Bull World Health Organ. 1992;70(3):347-58.
As the effectiveness of mebendazole and albendazole in patients with echinococcosis has been found to vary, we investigated some of the factors likely to be responsible. A total of 79 patients who were treated with mebendazole (44 patients) or albendazole (35 patients) were included in the study. Evaluation of the treatment results was based on the changes in cyst morphology, as evidenced by the results of X-ray radiography, sonography, and computed tomography, and on analysis of the findings in relation to parasitic and drug factors. The response of cysts according to their site did not vary much, with the exception of the poor response of bone cysts. A more important factor seems to be cyst size, since the treatment was more efficacious against smaller and younger cysts. The presence of daughter cysts should be regarded as an unfavourable factor for treatment response. Cyst multiplicity did not present insurmountable difficulties, provided the cysts were small and a prolonged course of therapy was undergone. The choice of drug used for the therapy was important, with the results supporting the advantage of albendazole. In planning the chemotherapy of hydatid disease, factors such as cyst condition and drug used should therefore be taken into consideration.
由于已发现甲苯咪唑和阿苯达唑对棘球蚴病患者的疗效存在差异，我们对一些可能起作用的因素进行了调查。共有79例接受甲苯咪唑治疗（44例）或阿苯达唑治疗（35例）的患者纳入本研究。治疗结果的评估基于囊肿形态的变化，这可通过X线摄影、超声检查和计算机断层扫描结果得到证实，还基于对与寄生虫和药物因素相关的研究结果的分析。除骨囊肿反应较差外，囊肿根据其部位的反应变化不大。一个更重要的因素似乎是囊肿大小，因为治疗对较小和较年轻的囊肿更有效。存在子囊应被视为治疗反应的不利因素。如果囊肿较小且接受了较长疗程的治疗，囊肿多发并不会带来无法克服的困难。治疗所用药物的选择很重要，结果支持阿苯达唑的优势。因此，在规划包虫病的化疗时，应考虑囊肿状况和所用药物等因素。
