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人型支原体、肺炎支原体和解脲脲原体对新型喹诺酮OPC 17116的敏感性

Susceptibilities of Mycoplasma hominis, Mycoplasma pneumoniae, and Ureaplasma urealyticum to a new quinolone, OPC 17116.

作者信息

Kenny G E, Cartwright F D

机构信息

Department of Pathobiology, University of Washington, Seattle 98195.

出版信息

Antimicrob Agents Chemother. 1993 Aug;37(8):1726-7. doi: 10.1128/AAC.37.8.1726.

DOI:10.1128/AAC.37.8.1726
PMID:8215294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188054/
Abstract

The susceptibilities of human mycoplasmas to OPC 17116 (Otsuka America Pharmaceutical, Inc., Rockville, Md.) and temafloxacin (Abbott Laboratories, Chicago, Ill.) were determined by the agar dilution method and were compared with those to sparfloxacin and ofloxacin. The MICs of OPC 17116 for 90% of Mycoplasma pneumoniae (0.25 microgram/ml) and Mycoplasma hominis (0.125 micrograms/ml) isolates tested were closely similar to those of sparfloxacin and were four- to eightfold greater than those of ofloxacin. Temafloxacin was two- to fourfold more active than ofloxacin. Ureaplasma urealyticum was less susceptible; the MICs of OPC 17116 and temafloxacin for 90% of isolates tested were 2 and 4.0 micrograms/ml, respectively.

摘要

采用琼脂稀释法测定了人型支原体对OPC 17116（大冢美国制药公司，马里兰州罗克维尔）和替马沙星（雅培实验室，伊利诺伊州芝加哥）的敏感性，并与它们对司帕沙星和氧氟沙星的敏感性进行了比较。OPC 17116对90%受试肺炎支原体（0.25微克/毫升）和人型支原体（0.125微克/毫升）分离株的最低抑菌浓度与司帕沙星的最低抑菌浓度非常相似，比氧氟沙星的最低抑菌浓度高4至8倍。替马沙星的活性比氧氟沙星高2至4倍。解脲脲原体的敏感性较低；OPC 17116和替马沙星对90%受试分离株的最低抑菌浓度分别为2微克/毫升和4.0微克/毫升。