新型喹诺酮类药物OPC - 17116、氧氟沙星及司帕沙星对肺炎衣原体的体外活性
In vitro activities of OPC-17116, a new quinolone; ofloxacin; and sparfloxacin against Chlamydia pneumoniae.
作者信息
Roblin P M, Montalban G, Hammerschlag M R
机构信息
Department of Pediatrics, State University of New York Health Science Center at Brooklyn 11203.
出版信息
Antimicrob Agents Chemother. 1994 Jun;38(6):1402-3. doi: 10.1128/AAC.38.6.1402.
Abstract
The in vitro susceptibilities of 12 strains of Chlamydia pneumonia to a new quinolone, OPC-17116; ofloxacin; and sparfloxacin were determined. OPC-17116 was slightly less active than sparfloxacin but more active than ofloxacin, with a MIC for 90% of strains tested and a minimal chlamydiacidal concentration for 90% of strains tested of 0.5 micrograms/ml.
摘要
测定了12株肺炎衣原体对一种新型喹诺酮类药物OPC - 17116、氧氟沙星和司帕沙星的体外敏感性。OPC - 17116的活性略低于司帕沙星，但高于氧氟沙星，其对90%受试菌株的最低抑菌浓度（MIC）和对90%受试菌株的最低杀衣原体浓度为0.5微克/毫升。
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