Madou M, Tierney M J
Teknekron Sensor Development Corporation, Menlo Park, CA 94025.
Appl Biochem Biotechnol. 1993 Apr-May;41(1-2):109-28. doi: 10.1007/BF02918537.
Silicon microsensors have been very successful over the last decade in a wide variety of applications. Although commercialization of silicon-based biosensors has been slow, careful applications of microfabrication technologies to the development of biosensors will drive the formation of many new markets. The most promising high-volume, emerging markets include clinical analysis, health care, and environmental. For example, the worldwide sales of clinical sensors are expected to reach several hundreds of millions by 2000, whereas the total worldwide market for biosensors is forecast to reach $1 billion by the year 2000. In this article, an overview of current and potential markets is presented with an emphasis on technological barriers to overcome before biosensors will become more widely accepted. We start by explaining the relative success of physical sensors compared to biosensors. Subsequently, we review several biosensor approaches and techniques and their associated problems. Finally, the markets that these sensors are meant to serve are analyzed.
在过去十年中，硅微传感器在各种各样的应用中取得了巨大成功。尽管基于硅的生物传感器商业化进程缓慢，但将微制造技术谨慎应用于生物传感器的开发将推动许多新市场的形成。最有前景的高产量新兴市场包括临床分析、医疗保健和环境领域。例如，预计到2000年临床传感器的全球销售额将达到数亿美元，而生物传感器的全球总市场预计到2000年将达到10亿美元。本文概述了当前和潜在市场，重点介绍了在生物传感器被更广泛接受之前需要克服的技术障碍。我们首先解释物理传感器相对于生物传感器取得相对成功的原因。随后，我们回顾了几种生物传感器方法和技术及其相关问题。最后，分析了这些传感器旨在服务的市场。
