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全腹照射与胃肠外营养:犬的实验研究

Total abdominal irradiation and parenteral nutrition: an experimental study in the dog.

作者信息

Dubois J B, Joyeux H, Yakoun M, Pourquier H, Solassol C

出版信息

Biomedicine. 1976 Jun;25(4):123-5.

PMID:821550
Abstract

The influence of parenteral nutrition on digestive tolerance was studied in 26 dogs receiving total abdominal irradiation, (1 110 rads were delivered in a single dose at mid-thickness of the abdomen). We studied enzymatic perturbations (lactase, maltase, alkaline phosphatase and enterokinase) in the duodenum, jejunum and ileum and we observed a correction of the 75% decrease of the intestinal enzymatic activities after total abdominal irradiation in the dogs fed exclusively by parenteral routes while the dogs fed orally died in few days with severe digestive and metabolic disturbances.

摘要

在26只接受全腹照射的犬(在腹部中点厚度处单次给予1110拉德辐射剂量)中研究了肠外营养对消化耐受性的影响。我们研究了十二指肠、空肠和回肠中的酶扰动(乳糖酶、麦芽糖酶、碱性磷酸酶和肠激酶),并且我们观察到,仅通过肠外途径喂养的犬在全腹照射后肠道酶活性降低了75%,但得到了纠正,而口服喂养的犬在几天内死亡,伴有严重的消化和代谢紊乱。

相似文献

1
Total abdominal irradiation and parenteral nutrition: an experimental study in the dog.全腹照射与胃肠外营养:犬的实验研究
Biomedicine. 1976 Jun;25(4):123-5.
2
Effect of ionizing radiation on the enzymes of the intestinal mucosa of rats at different time intervals after abdominal irradiation.腹部照射后不同时间间隔电离辐射对大鼠肠黏膜酶的影响。
Radiat Res. 1972 Jan;49(1):213-25.
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Strahlentherapie. 1975 Oct;150(4):427-32.
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J Reprod Fertil Suppl. 1975 Oct(23):717-23.
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[Determination of the activity of lactase, maltase and alkaline phosphatase in the mucosa of the small intestine of healthy persons].[健康人小肠黏膜中乳糖酶、麦芽糖酶和碱性磷酸酶活性的测定]
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Morphological study of the effect of abdominal compression on acute intestinal radiation syndrome. II. Local irradiation with 30 Gy.腹部压迫对急性肠道放射综合征影响的形态学研究。II. 30 Gy局部照射
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引用本文的文献

1
[Cytostatica and small intestine (author's transl)].[细胞抑制剂与小肠(作者译)]
Klin Wochenschr. 1978 Jun 15;56(12):579-92. doi: 10.1007/BF01477006.