单剂量静脉注射帕米膦酸盐治疗骨佩吉特病
Treatment of Paget's disease of bone with single dose intravenous pamidronate.
作者信息
Watts R A, Skingle S J, Bhambhani M M, Pountain G, Crisp A J
机构信息
Department of Rheumatology, Addenbrooke's Hospital, Cambridge, United Kingdom.
出版信息
Ann Rheum Dis. 1993 Aug;52(8):616-8. doi: 10.1136/ard.52.8.616.
OBJECTIVES
To assess the efficacy of a single intravenous infusion of pamidronate in Paget's disease of bone.
METHODS
Fourteen patients with active Paget's disease (raised serum alkaline phosphatase, bone pain or neurological involvement) were treated with a single intravenous infusion of 105 mg pamidronate. Patients were assessed for biochemical and clinical improvement for up to two years following treatment. A further infusion was given following symptomatic relapse (pain at a known site of pagetic involvement).
RESULTS
Serum alkaline phosphatase fell following treatment, with a nadir 5.9 months after treatment. Bone pain was improved in nine of 12 patients after six months. Retreatment of four patients resulted in a similar response.
CONCLUSION
Single dose intravenous pamidronate (105 mg) is a convenient and effective treatment for Paget's disease.
目的
评估单次静脉输注帕米膦酸盐治疗骨Paget病的疗效。
方法
14例活动性骨Paget病（血清碱性磷酸酶升高、骨痛或神经受累）患者接受单次静脉输注105mg帕米膦酸盐治疗。治疗后长达两年对患者进行生化和临床改善评估。症状复发（Paget病累及部位疼痛）后再次输注。
结果
治疗后血清碱性磷酸酶下降，治疗后5.9个月降至最低点。12例患者中有9例在6个月后骨痛得到改善。4例患者再次治疗后有类似反应。
结论
单次静脉注射帕米膦酸盐（105mg）是治疗骨Paget病的一种方便有效的方法。
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