Magann E F, Martin R W, Isaacs J D, Blake P G, Morrison J C, Martin J N
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505.
Aust N Z J Obstet Gynaecol. 1993 May;33(2):127-31. doi: 10.1111/j.1479-828x.1993.tb02374.x.
This study was undertaken to determine maternal impact of corticosteroids administered for the promotion of fetal lung maturity in mothers with the HELLP syndrome. Twenty-seven of 427 women with the HELLP syndrome treated between 1980-1991 received a full course of steroids prior to preterm delivery. This group was compared to 27 matched control patients with the HELLP syndrome who received no corticosteroids. Subjects were matched for maternal age, race, sex of the fetus, and severity of the HELLP syndrome. The antepartum platelet count stabilized or increased in 25 of 27 steroid-treated women in contrast to 0 of 15 control women (p < 0.00001). In comparison to control patients, LDH serum concentrations in steroid-treated patients stabilized or decreased and the SGOT/AST and SGPT/ALT stabilized or decreased during therapy (p < 0.005). The interval from delivery to platelet nadir in patients with Class III HELLP syndrome was shorter in the steroid-treated group (p < 0.008) than in untreated patients.
本研究旨在确定在患有HELLP综合征的母亲中使用皮质类固醇促进胎儿肺成熟对母亲的影响。1980年至1991年间接受治疗的427例HELLP综合征女性中，有27例在早产前接受了完整疗程的类固醇治疗。将该组与27例匹配的未接受皮质类固醇治疗的HELLP综合征对照患者进行比较。根据产妇年龄、种族、胎儿性别和HELLP综合征的严重程度对受试者进行匹配。27例接受类固醇治疗的女性中有25例产前血小板计数稳定或增加，而15例对照女性中无一例如此（p<0.00001）。与对照患者相比，接受类固醇治疗的患者血清乳酸脱氢酶（LDH）浓度稳定或降低，治疗期间谷草转氨酶/天冬氨酸转氨酶（SGOT/AST）和谷丙转氨酶/丙氨酸转氨酶（SGPT/ALT）稳定或降低（p<0.005）。在III级HELLP综合征患者中，类固醇治疗组从分娩到血小板最低点的间隔时间比未治疗患者短（p<0.008）。
