Magann E F, Graves G R, Roberts W E, Blake P G, Morrison J C, Martin J N
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505.
Aust N Z J Obstet Gynaecol. 1993 May;33(2):131-5. doi: 10.1111/j.1479-828x.1993.tb02375.x.
This study was undertaken to determine retrospectively, in women with the HELLP syndrome, the perinatal effects of corticosteroid administration for promotion of fetal lung maturity. Twenty-seven of 427 women with the HELLP syndrome treated between 1980 and 1991 received a full course of steroids prior to preterm delivery. They were compared to 27 control patients with the HELLP syndrome matched for maternal age, severity of disease, gestational age, race, and sex of the fetus. Respiratory distress requiring mechanical ventilation occurred in 13 of 27 neonates who received steroid administration and in 23 of 27 who did not receive steroids (p < 0.001). The average stay in the neonatal intensive care unit was 29.8 +/- 50.6 days for the steroid-treated group and 45.2 +/- 35.3 days for the group without steroid use (p = NS). The incidence of neonatal deaths, intraventricular haemorrhage type III and IV, necrotizing enterocolitis, and retrolental fibroplasia was greater in the control group but the difference was not statistically significant.
本研究旨在回顾性确定患有HELLP综合征的女性中，给予皮质类固醇以促进胎儿肺成熟的围产期影响。1980年至1991年间接受治疗的427例HELLP综合征女性中，有27例在早产前接受了一整个疗程的类固醇治疗。将她们与27例患有HELLP综合征的对照患者进行比较，这些对照患者在产妇年龄、疾病严重程度、孕周、种族和胎儿性别方面相匹配。接受类固醇治疗的27例新生儿中有13例发生需要机械通气的呼吸窘迫，未接受类固醇治疗的27例中有23例发生（p<0.001）。接受类固醇治疗组在新生儿重症监护病房的平均住院时间为29.8±50.6天，未使用类固醇组为45.2±35.3天（p=无显著性差异）。对照组新生儿死亡、III级和IV级脑室内出血、坏死性小肠结肠炎和晶状体后纤维增生的发生率更高，但差异无统计学意义。
