大鼠和人类大脑中肌醇的减少。
Decrease in cerebral inositols in rats and humans.
作者信息
Moats R A, Lien Y H, Filippi D, Ross B D
机构信息
Huntingdon Medical Research Institutes, Pasadena, CA 91105.
出版信息
Biochem J. 1993 Oct 1;295 ( Pt 1)(Pt 1):15-8. doi: 10.1042/bj2950015.
Abstract
Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain. The portacaval-shunted rat may therefore be a useful model for the investigation of neurochemical pathways containing myoinositol, which are modulated not only in hepatic encephalopathy but also in diabetes mellitus and Alzheimer's disease.
摘要
患有门腔分流术的大鼠以及患有肝性脑病的人类大脑中都出现了严重的肌醇耗竭。因此，门腔分流术大鼠可能是研究含肌醇神经化学途径的有用模型，这些途径不仅在肝性脑病中受到调节，在糖尿病和阿尔茨海默病中也会受到调节。
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Decrease in cerebral inositols in rats and humans.大鼠和人类大脑中肌醇的减少。
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