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大鼠和人类大脑中肌醇的减少。

Decrease in cerebral inositols in rats and humans.

作者信息

Moats R A, Lien Y H, Filippi D, Ross B D

机构信息

Huntingdon Medical Research Institutes, Pasadena, CA 91105.

出版信息

Biochem J. 1993 Oct 1;295 ( Pt 1)(Pt 1):15-8. doi: 10.1042/bj2950015.

DOI:10.1042/bj2950015
PMID:8216210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1134813/
Abstract

Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain. The portacaval-shunted rat may therefore be a useful model for the investigation of neurochemical pathways containing myoinositol, which are modulated not only in hepatic encephalopathy but also in diabetes mellitus and Alzheimer's disease.

摘要

患有门腔分流术的大鼠以及患有肝性脑病的人类大脑中都出现了严重的肌醇耗竭。因此，门腔分流术大鼠可能是研究含肌醇神经化学途径的有用模型，这些途径不仅在肝性脑病中受到调节，在糖尿病和阿尔茨海默病中也会受到调节。

相似文献

1
Decrease in cerebral inositols in rats and humans.大鼠和人类大脑中肌醇的减少。
Biochem J. 1993 Oct 1;295 ( Pt 1)(Pt 1):15-8. doi: 10.1042/bj2950015.
2
Scyllo-inositol depletion in hepatic encephalopathy.肝性脑病中 scyllo-肌醇的耗竭
Life Sci. 1994;54(20):1507-12. doi: 10.1016/0024-3205(94)90018-3.
3
Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema.大鼠门腔静脉吻合术后的谷氨酰胺、肌醇及脑内有机渗透物质：对氨诱导脑水肿的影响
Hepatology. 1996 Oct;24(4):919-23. doi: 10.1002/hep.510240427.
4
Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy.低渗状态和肝性脑病时人脑肌醇的质子磁共振波谱研究
Gastroenterology. 1994 Nov;107(5):1475-80. doi: 10.1016/0016-5085(94)90552-5.
5
[Free aminoacids and cerebral lipids in the rat following porto-cava anastomosis].[大鼠门腔静脉吻合术后的游离氨基酸和脑脂质]
Arch Sci Med (Torino). 1973 Jul-Sep;130(3):198-202.
6
[Metabolic consequences of experimental portacaval shunts].
Pathol Biol (Paris). 1979 Apr;27(4):192-6.
7
Chronic inhibition of brain protein synthesis after portacaval shunting. A possible pathogenic mechanism in chronic hepatic encephalopathy in the rat.
Neurology. 1978 Mar;28(3):233-8. doi: 10.1212/wnl.28.3.233.
8
Reversal of behavioral changes in rats subjected to portacaval shunt with oral neomycin therapy.
Hepatology. 1994 May;19(5):1245-50.
9
[Effect of bromocriptine on brain levels of noradrenaline, dopamine and serotonin in experimental portosystemic encephalopathy].
Rev Clin Esp. 1983 Mar 15;168(5):339-41.
10
Preclinical models of hepatic encephalopathy.肝性脑病的临床前模型
Curr Protoc Neurosci. 2001 May;Chapter 9:Unit9.3. doi: 10.1002/0471142301.ns0903s08.

引用本文的文献

1
Measuring brain uptake and incorporation into brain phosphatidylinositol of plasma myo-[2H6]inositol in unanesthetized rats: an approach to estimate in vivo brain phosphatidylinositol turnover.测量未麻醉大鼠血浆肌醇-[2H6]肌醇的脑摄取及其掺入脑磷脂酰肌醇的情况：一种估计体内脑磷脂酰肌醇周转率的方法。
Neurochem Res. 2006 Jun;31(6):759-65. doi: 10.1007/s11064-006-9080-4. Epub 2006 Jun 22.
2
Hepatic encephalopathy as a complication of liver disease.肝性脑病作为肝病的一种并发症。
World J Gastroenterol. 2001 Apr;7(2):152-6. doi: 10.3748/wjg.v7.i2.152.
3
Effect of ammonia and methionine sulfoximine on myo-inositol transport in cultured astrocytes.氨和蛋氨酸亚砜亚胺对培养星形胶质细胞中肌醇转运的影响。
Neurochem Res. 1999 Jan;24(1):51-9. doi: 10.1023/a:1020928029845.

本文引用的文献

1
THE BIOSYNTHESIS OF FREE AND PHOSPHATIDE MYO-INOSITOL FROM GLUCOSE BY MAMMALIAN TISSUE SLICES.哺乳动物组织切片从葡萄糖合成游离型和磷脂酰肌醇型肌醇的生物合成过程
J Biol Chem. 1963 Oct;238:3224-8.
2
Portacaval anastomosis: brain and plasma metabolite abnormalities and the effect of nutritional therapy.门腔静脉吻合术：脑和血浆代谢物异常及营养治疗的效果
J Neurochem. 1984 Sep;43(3):697-705. doi: 10.1111/j.1471-4159.1984.tb12789.x.
3
Inositol trisphosphate and diacylglycerol as second messengers.肌醇三磷酸和二酰甘油作为第二信使。
Biochem J. 1984 Jun 1;220(2):345-60. doi: 10.1042/bj2200345.
4
Reduced phosphoinositide concentrations in anterior temporal cortex of Alzheimer-diseased brains.
J Neurochem. 1987 Apr;48(4):1018-21. doi: 10.1111/j.1471-4159.1987.tb05619.x.
5
Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolites.人体大脑不同区域的活体局部质子核磁共振波谱分析。脑代谢物的弛豫时间和浓度。
Magn Reson Med. 1989 Jul;11(1):47-63. doi: 10.1002/mrm.1910110105.
6
Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study.急性肝衰竭动物模型体内脑代谢物的观察：一项1H和31P核磁共振研究
J Neurochem. 1989 Jul;53(1):102-10. doi: 10.1111/j.1471-4159.1989.tb07300.x.
7
Effects of hypernatremia on organic brain osmoles.高钠血症对脑内有机渗透物的影响。
J Clin Invest. 1990 May;85(5):1427-35. doi: 10.1172/JCI114587.
8
Hyperammonaemia causes many of the changes found after portacaval shunting.高氨血症会引发门腔分流术后出现的许多变化。
Biochem J. 1990 Dec 1;272(2):311-7. doi: 10.1042/bj2720311.
9
Localized 13C NMR spectroscopy of myo-inositol in the human brain in vivo.人脑活体中肌醇的局部¹³C核磁共振波谱分析。
Magn Reson Med. 1992 May;25(1):204-10. doi: 10.1002/mrm.1910250121.
10
Clinical tools for the 90s: magnetic resonance spectroscopy and metabolite imaging.90年代的临床工具：磁共振波谱学与代谢物成像。
Eur J Radiol. 1992 Mar-Apr;14(2):128-40. doi: 10.1016/0720-048x(92)90226-y.