人脑活体中肌醇的局部¹³C核磁共振波谱分析。

Localized 13C NMR spectroscopy of myo-inositol in the human brain in vivo.

作者信息

Gruetter R, Rothman D L, Novotny E J, Shulman R G

机构信息

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut.

出版信息

Magn Reson Med. 1992 May;25(1):204-10. doi: 10.1002/mrm.1910250121.

DOI:10.1002/mrm.1910250121

PMID:1593953

Abstract

Natural abundance 13C NMR spectra obtained from 144-cm3 volumes in the human brain contained well-resolved resonances of myo-inositol after 60 min of data accumulation. A mean concentration of 7.2 +/- 0.5 mumol/g (+/- SE, n = 7) was calculated from the comparison with phantoms. 13C NMR spectroscopy thus provides a complementary role in the quantitation of metabolites also observed in the crowded 1H spectrum.

摘要

从人脑144立方厘米体积中获取的天然丰度13C核磁共振谱，在积累60分钟数据后，包含了分辨率良好的肌醇共振峰。通过与体模比较，计算出平均浓度为7.2±0.5微摩尔/克（±标准误，n = 7）。因此，13C核磁共振波谱学在定量分析拥挤的1H谱中也能观察到的代谢物方面发挥着补充作用。