拉扎罗类药物U74500A和利多氟嗪对UW液肝脏保存的保护作用。
Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution.
作者信息
Jacobsson J, Sundberg R, Rilo H L, Gasbarrini A, Starzl T E, Van Thiel D
机构信息
Department of Surgery, University of Pittsburgh, PA 15213.
出版信息
Transpl Int. 1993;6(5):281-4. doi: 10.1007/BF00336028.
Abstract
The effect of adding a 21-aminosteroid, U74500A, and a Ca2+ antagonist, lidoflazine, alone and together to UW solution was assessed in a rat liver preservation model. Following preservation, the livers were reperfused using a closed circuit, and the release of hepatocellular enzymes (ASAT, ALAT, and LDH) into the perfusate was determined with increasing time. Both drugs reduced the amount of enzymes lost from the liver. The combination of the two drugs was better than either drug alone. These data suggest that both agents may be of value in organ preservation for clinical liver transplantation.
摘要
在大鼠肝脏保存模型中评估了单独及联合添加一种21-氨基类固醇U74500A和一种钙拮抗剂利多氟嗪至UW溶液的效果。保存后，使用闭合回路对肝脏进行再灌注，并随着时间的增加测定肝细胞酶（谷草转氨酶、谷丙转氨酶和乳酸脱氢酶）向灌注液中的释放量。两种药物均减少了肝脏中损失的酶量。两种药物联合使用比单独使用任一药物的效果更好。这些数据表明，这两种药物在临床肝移植的器官保存中可能都具有价值。
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Liver preservation with lidoflazine and the University of Wisconsin solution: a dose-finding study.利多氟嗪与威斯康星大学溶液用于肝脏保存的剂量探索性研究。
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