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妊娠和哺乳期补充母体 VE-M16V 和 scGOS/lcFOS 对母体免疫系统和乳汁成分的影响。

Impact of maternal ve M-16V and scGOS/lcFOS supplementation during pregnancy and lactation on the maternal immune system and milk composition.

机构信息

Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), Barcelona, Spain.

Nutrition and Food Safety Research Institute (INSA-UB), Santa Coloma de Gramenet, Spain.

出版信息

Front Immunol. 2024 Jun 21;15:1418594. doi: 10.3389/fimmu.2024.1418594. eCollection 2024.

DOI:10.3389/fimmu.2024.1418594
PMID:38975337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11224147/
Abstract

INTRODUCTION

Maternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal disorders. This study focused on the immunomodulatory effects of M-16V and short chain galacto-oligosaccharides (scGOS)/long chain fructo-oligosachairdes (lcFOS), including systemic and mucosal compartments and milk composition.

METHODS

Lewis rats were orally administered with the synbiotic or vehicle during pregnancy (21 days) and lactation (21 days). At the weaning day, small intestine (SI), mammary gland (MG), adipose tissue, milk, mesenteric lymph nodes (MLN), salivary gland (SG), feces and cecal content were collected from the mothers.

RESULTS

The immunoglobulinome profile showed increased IgG2c in plasma and milk, as well as elevated sIgA in feces at weaning. The supplementation improved lipid metabolism through enhanced brown adipose tissue activity and reinforced the intestinal barrier by increasing the expression of , , and . The higher production of short chain fatty acids in the cecum and increased counts suggest a potential positive impact on the gastrointestinal tract.

DISCUSSION

These findings indicate that maternal synbiotic supplementation during gestation and lactation improves their immunological status and improved milk composition.

摘要

简介

孕期和哺乳期补充母体共生元可显著影响免疫系统。益生菌和益生元通过预防或改善肠道疾病等方式对免疫系统产生积极影响。本研究专注于 M-16V 和短链半乳糖寡糖（scGOS）/长链果糖寡糖（lcFOS）的免疫调节作用，包括全身和黏膜区室以及乳汁成分。

方法

在孕期（21 天）和哺乳期（21 天）期间，Lewis 大鼠经口给予共生元或载体。在断奶日，从母亲体内收集小肠（SI）、乳腺（MG）、脂肪组织、乳汁、肠系膜淋巴结（MLN）、唾液腺（SG）、粪便和盲肠内容物。

结果

免疫球蛋白组显示，断奶时血浆和乳汁中的 IgG2c 增加，粪便中的分泌型 IgA（sIgA）也升高。补充剂通过增强棕色脂肪组织的活性改善了脂质代谢，并通过增加 、 和 的表达增强了肠道屏障。盲肠中短链脂肪酸的产量增加和 计数的增加表明其对胃肠道可能具有潜在的积极影响。

讨论

这些发现表明，孕期和哺乳期母体共生元的补充可改善其免疫状态和乳汁成分。

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2
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3
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Mol Nutr Food Res. 2024 Nov;68(22):e2400377. doi: 10.1002/mnfr.202400377. Epub 2024 Oct 29.
茯砖茶多糖通过肠道微生物群控制促进脂肪细胞棕色化和产热来预防肥胖。
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4
Krasch polysaccharide promotes adipose thermogenesis and decreases obesity by shaping the gut microbiota.克拉斯多糖通过塑造肠道微生物群促进脂肪产热并减轻肥胖。
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5
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