Wu J M, Cheng T, Sun S D, Niu D D, Zhang J X, Wang S H, Tang J, Tang C S
Laboratory of Cardiopulmonary Endocrinology, Beijing Medical University, PRC.
Sci China B. 1993 Aug;36(8):948-53.
By means of cell culture, 3H-thymidine (3H-TdR) incorporation and c-fos oncogene dot plotting technique, it was found that endothelin (ET) and angiotensin (ANG II) could promote proliferation and DNA synthesis of cultured vascular smooth muscle cells (VSMCs) and myocardial cells, and stimulate expression of c-fos oncogene of VSMCs. However, atrial natriuretic peptide (ANP) antagonizes the above effects of ET and ANG II.
