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[来自海风藤(Piper futokadsura Sied. et Zucc)的抗血小板活化因子成分,2,5 - 二芳基四氢呋喃型木脂素]

[Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc].

作者信息

Chen Z N, Yu P Z, Xu P J

机构信息

Department of Chemistry, Shanghai Second Medical University.

出版信息

Zhongguo Zhong Yao Za Zhi. 1993 May;18(5):292-4, 318.

PMID:8216803
Abstract

Besides the known components kadsurenone, futoquinol and futoxide, three anti-platelet activating factor principles have been found from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng. They were separated and identified as galgravin, galbelgin and veraguensin on the basis of HPLC and spectral analysis. The natural existence of these three anti-PAF constituents in haifengteng is reported for the first time.

摘要

除了已知成分海风藤酮、风藤醌醇和风藤素外,还从中药海风藤(胡椒科植物风藤)的茎部发现了三种抗血小板活化因子成分。通过高效液相色谱法(HPLC)和光谱分析,它们被分离并鉴定为加格拉文、加贝辛和维拉古辛。首次报道了这三种抗血小板活化因子成分在海风藤中的天然存在情况。

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Chem Biodivers. 2025 Mar;22(3):e202401848. doi: 10.1002/cbdv.202401848. Epub 2024 Nov 23.
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Pharmacokinetic and Bioavailability Studies of Galgravin after Oral and Intravenous Administration to Rats Using HPLC-MS/MS Method.采用 HPLC-MS/MS 法研究大鼠口服和静脉注射加拉格雷后药代动力学和生物利用度。
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Effects of veraguensin and galgravin on osteoclast differentiation and function.
维拉古敏素和加拉文对破骨细胞分化和功能的影响。
Cytotechnology. 2012 May;64(3):315-22. doi: 10.1007/s10616-011-9416-z. Epub 2012 Apr 24.