Jung K Y, Kim D S, Oh S R, Park S H, Lee I S, Lee J J, Shin D H, Lee H K
Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience & Biotechnology, Yusong P.O. Box 115, Taejon 305-600, Korea.
J Nat Prod. 1998 Jun 26;61(6):808-11. doi: 10.1021/np970445+.
In a search for platelet-activating-factor (PAF) antagonists, two new lignan compounds were isolated from the Chinese crude drug shin-i, the flower buds of Magnolia fargesii. Their structures were elucidated as (2S,3R,4R)-tetrahydro-2-(3,4-dimethoxyphenyl)-4-(3, 4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone A, 1) and (2S,3R, 4R)-tetrahydro-2-(3,4,5-trimethoxyphenyl)-4-(3, 4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone B, 2). Magnones A and B showed antagonistic activity against PAF in the [3H]PAF receptor binding assay with the IC50 values of 3.8 x 10(-5) M and 2.7 x 10(-5) M, respectively.
在寻找血小板活化因子（PAF）拮抗剂的过程中，从中国天然药物辛夷（望春花的花蕾）中分离出两种新的木脂素化合物。它们的结构被鉴定为(2S,3R,4R)-四氢-2-(3,4-二甲氧基苯基)-4-(3,4-二甲氧基苯甲酰基)-3-(羟甲基)呋喃（木兰酮A，1）和(2S,3R,4R)-四氢-2-(3,4,5-三甲氧基苯基)-4-(3,4-二甲氧基苯甲酰基)-3-(羟甲基)呋喃（木兰酮B，2）。在[3H]PAF受体结合试验中，木兰酮A和B对PAF表现出拮抗活性，IC50值分别为3.8×10(-5)M和2.7×10(-5)M。
