Reed S G, Scott P
Seattle Biomedical Research Institute.
Curr Opin Immunol. 1993 Aug;5(4):524-31. doi: 10.1016/0952-7915(93)90033-o.
Intracellular pathogens, particularly those that inhabit lymphocytes and macrophages, represent unique challenges to the immune system. Leishmania are protozoan parasites that replicate exclusively in macrophages and are thus in an excellent position to influence lymphocyte responses. T cell responses are critical in determining the outcome of infections with Leishmania. In both murine and human infections, strong T helper type 2 responses have been associated with disease, and a decreased or absent T helper type 2 response has been associated with healing.
细胞内病原体，尤其是那些寄生于淋巴细胞和巨噬细胞内的病原体，给免疫系统带来了独特的挑战。利什曼原虫是原生动物寄生虫，仅在巨噬细胞内复制，因此极有可能影响淋巴细胞反应。T细胞反应在决定利什曼原虫感染的结果中起着关键作用。在小鼠和人类感染中，强烈的2型辅助性T细胞反应都与疾病相关，而减弱或缺失的2型辅助性T细胞反应则与愈合相关。
