Tsunoda Y
Department of Faculty Science, Hokkaido University, Sapporo, Japan.
Biochim Biophys Acta. 1993 Oct 29;1154(2):105-56. doi: 10.1016/0304-4157(93)90008-c.
In the cells of higher eukaryotic organisms, there are several messenger pathways of intracellular signal transduction, such as the inositol 1,4,5-trisphosphate/Ca2+ signal, voltage-dependent and -independent Ca2+ channels, adenylate cyclase/cyclic adenosine 3',5'-monophosphate, guanylate cyclase/cyclic guanosine 3',5'-monophosphate, diacylglycerol/protein kinase C, and growth factors/tyrosine kinase/tyrosine phosphatase. These pathways are present in different cell types and impinge on each other for the modulation of the cell function. Ca2+ is one of the most ubiquitous intracellular messengers mediating transcellular communication in a wide variety of cell types. Over the last decades it has become clear that the activation of many types of cells is accompanied by an increase in cytosolic free Ca2+ concentration ([Ca2+]i) that is thought to play an important part in the sequence of events occurring during cell activation. The Ca2+ signal can be divided into two categories: receptor- and voltage-operated Ca2+ signal. This review describes and integrates some recent views of receptor-operated Ca2+ signaling and crosstalk in the context of stimulus-secretion coupling.
在高等真核生物的细胞中，存在多种细胞内信号转导的信使途径，如肌醇1,4,5 - 三磷酸/Ca2+信号、电压依赖性和非依赖性Ca2+通道、腺苷酸环化酶/环磷酸腺苷、鸟苷酸环化酶/环磷酸鸟苷、二酰基甘油/蛋白激酶C以及生长因子/酪氨酸激酶/酪氨酸磷酸酶。这些途径存在于不同的细胞类型中，并且相互影响以调节细胞功能。Ca2+是介导多种细胞类型跨细胞通讯的最普遍存在的细胞内信使之一。在过去几十年中，已经清楚地表明，许多类型细胞的激活伴随着胞质游离Ca2+浓度（[Ca2+]i）的增加，这被认为在细胞激活过程中发生的一系列事件中起重要作用。Ca2+信号可分为两类：受体介导的和电压门控的Ca2+信号。本综述在刺激 - 分泌偶联的背景下描述并整合了受体介导的Ca2+信号传导和相互作用的一些最新观点。
