Ekman M R, Grayston J T, Visakorpi R, Kleemola M, Kuo C C, Saikku P
Department of Virology, University of Helsinki, Finland.
Clin Infect Dis. 1993 Sep;17(3):420-5. doi: 10.1093/clinids/17.3.420.
A prospective observational study of an epidemic of infection due to Chlamydia pneumoniae strain TWAR in Finnish military trainees provided new information on immunity following infection, the range of clinical syndromes and complications, and cell culture isolation. One-half of the trainees studied (43 of 86) had laboratory evidence of C. pneumoniae infection. The etiologic association of C. pneumoniae with disease was strengthened by the sharp increase in cases of pneumonia and in outpatient visits for acute respiratory disease along with the laboratory evidence of infection. The pattern of serological response suggested that 23 of the trainees had a primary TWAR infection and 20 had a reinfection. Evidence that prior infection modified the illness included the frequency of hospitalization (12 with primary infections vs. 1 with reinfection), the development of pneumonia (10 vs. 0), and the requirement for repeated courses of antibiotic therapy (13 courses vs. 0). Isolation was more frequent in HL cells (n = 25) than in HeLa 229 cells (n = 10).
一项针对芬兰军事学员中肺炎衣原体TWAR菌株感染流行情况的前瞻性观察研究，提供了有关感染后免疫、临床综合征和并发症范围以及细胞培养分离方面的新信息。所研究的学员中有一半（86人中的43人）有肺炎衣原体感染的实验室证据。随着感染的实验室证据出现，肺炎病例和急性呼吸道疾病门诊就诊人数急剧增加，这加强了肺炎衣原体与疾病的病因学关联。血清学反应模式表明，23名学员有原发性TWAR感染，20名有再次感染。先前感染改变疾病的证据包括住院频率（原发性感染12人，再次感染1人）、肺炎的发生情况（10例对0例）以及重复抗生素治疗疗程的需求（13个疗程对0个疗程）。在HL细胞（n = 25）中分离比在HeLa 229细胞（n = 10）中更频繁。
