Juvonen R, Bloigu A, Paldanius M, Peitso A, Silvennoinen-Kassinen S, Harju T, Leinonen M, Saikku P
Department of Otorhinolaryngology, Kainuu Central Hospital, Kajaani, Finland.
Clin Microbiol Infect. 2008 Mar;14(3):207-12. doi: 10.1111/j.1469-0691.2007.01898.x. Epub 2007 Dec 5.
Chlamydia pneumoniae respiratory tract infections were studied in 512 male military conscripts (123 asthmatic and 389 non-asthmatic) taking part in 180-day service between July 2004 and July 2005 in Kajaani, Finland. Respiratory tract infections requiring a medical consultation were analysed prospectively. At baseline, at end of service, and during each episode of respiratory infection, blood samples were obtained for measurement of C. pneumoniae antibodies. Data concerning the clinical features of each infection episode were collected. Serological evidence of acute C. pneumoniae infection was found in 34 of the 512 conscripts with antibody data available, including 9.8% of the asthmatic subjects and 5.7% of the non-asthmatic subjects (p 0.111). A serological diagnosis could be made for 25 clinical episodes in 24 conscripts. The spectrum of respiratory tract infections included 13 episodes of mild upper respiratory tract infection and seven episodes of sinusitis, with five episodes involving asthma exacerbation. Two of three pneumonias were primary infections. Primary infections were diagnosed in five subjects, and re-infection/reactivation in 19 subjects, with the latter comprising 12 non-asthmatic subjects and seven asthmatic subjects (p 0.180). Prolonged infections were present in six asthmatic subjects and one non-asthmatic subject (p 0.001). A wide variety of respiratory tract infections, ranging from common cold to pneumonia, were associated with serologically confirmed C. pneumoniae infections. Infections were often mild, with common cold and sinusitis being the most common manifestations. Acute, rapidly resolved C. pneumoniae infections were equally common among asthmatic subjects and non-asthmatic subjects, whereas prolonged infections were more common among subjects with asthma.
对2004年7月至2005年7月在芬兰卡亚尼参加为期180天服役的512名男性应征入伍者（123名哮喘患者和389名非哮喘患者）的肺炎衣原体呼吸道感染情况进行了研究。对需要就医咨询的呼吸道感染进行了前瞻性分析。在基线、服役结束时以及每次呼吸道感染发作期间，采集血样以检测肺炎衣原体抗体。收集了每次感染发作的临床特征数据。在有抗体数据的512名应征入伍者中，有34人发现了急性肺炎衣原体感染的血清学证据，其中哮喘患者占9.8%，非哮喘患者占5.7%（p = 0.111）。对24名应征入伍者的25次临床发作做出了血清学诊断。呼吸道感染谱包括13次轻度上呼吸道感染发作和7次鼻窦炎发作，其中5次发作伴有哮喘加重。3例肺炎中有2例为原发性感染。5名受试者被诊断为原发性感染，19名受试者为再次感染/再激活，后者包括12名非哮喘受试者和7名哮喘受试者（p = 0.180）。6名哮喘受试者和1名非哮喘受试者存在持续性感染（p = 0.001）。从普通感冒到肺炎等各种各样的呼吸道感染都与血清学确诊的肺炎衣原体感染有关。感染通常较轻，普通感冒和鼻窦炎是最常见的表现。急性、迅速缓解的肺炎衣原体感染在哮喘受试者和非哮喘受试者中同样常见，而持续性感染在哮喘受试者中更为常见。
