Trajanoski Z, Wach P, Kotanko P, Ott A, Skraba F
Institut für Elektro- und Biomedizinische Technik, Technische Universität, Graz.
Biomed Tech (Berl). 1993 Sep;38(9):224-31. doi: 10.1515/bmte.1993.38.9.224.
A subcutaneous insulin absorption model is presented for parameter estimation from the time course of plasma insulin. Modifications of a published model were made for the absorption of soluble insulin and monomeric insulin analogues in the range of therapeutic concentrations and volumes. The modified diffusion-dissociation model with distributed parameters was approximated by a multiple-compartment model. Subcutaneous absorption of soluble insulin and monomeric insulin analogues with various volumes, concentrations, and injection depths was simulated. The model for soluble insulin exhibits volume, concentration, and injection depth dependent absorption, as experimentally observed. It was found that binding of soluble insulin in the subcutaneous tissue is negligible for U-40 and U-100 strengths. The absorption of identical doses (10 U) of soluble U-40 insulin was markedly faster (T-50% = 159.4 min) than the absorption of U-100 (T-50% = 196.2 min). According to the simulation results, the absorption rate of monomeric analogues is not dependent on concentration. No significant chances of the absorption rate could also be observed by varying volume and injection depth of the monomeric analogues.
本文提出了一种皮下胰岛素吸收模型，用于根据血浆胰岛素的时间进程进行参数估计。针对治疗浓度和体积范围内可溶性胰岛素和单体胰岛素类似物的吸收，对已发表的模型进行了修改。具有分布参数的修正扩散-解离模型由多室模型近似。模拟了不同体积、浓度和注射深度的可溶性胰岛素和单体胰岛素类似物的皮下吸收。如实验观察到的，可溶性胰岛素模型显示出吸收依赖于体积、浓度和注射深度。研究发现，对于U-40和U-100浓度的可溶性胰岛素，其在皮下组织中的结合可忽略不计。相同剂量（10 U）的可溶性U-40胰岛素的吸收明显快于U-100（T-50% = 159.4分钟对T-50% = 196.2分钟）。根据模拟结果，单体类似物的吸收速率不依赖于浓度。改变单体类似物的体积和注射深度，也未观察到吸收速率有显著变化。
