舒必利对映体在人和大鼠体内的处置情况。

Disposition of enantiomers of sulpiride in humans and rats.

作者信息

Kamizono A, Inotsume N, Fukushima S, Nakano M, Okamoto Y

机构信息

Department of Pharmaceutical Services, Kumamoto University Hospital, Japan.

出版信息

Biopharm Drug Dispos. 1993 Aug;14(6):475-81. doi: 10.1002/bdd.2510140603.

DOI:10.1002/bdd.2510140603

PMID:8218965

Abstract

Pharmacokinetics of sulpiride enantiomers after intravenous administration of (+/-)-, (+)-, and (-)-sulpiride was examined in humans and rats. Pharmacokinetics profiles were similar in (+)- and (-)-enantiomers after intravenous administration of (+/-)-sulpiride. Metabolic inversion at a chiral centre was not observed after intravenous administration of each enantiomer in rats.

摘要

在人和大鼠中研究了静脉注射（±）-、（+）-和（-）-舒必利后舒必利对映体的药代动力学。静脉注射（±）-舒必利后，（+）-和（-）-对映体的药代动力学特征相似。在大鼠中静脉注射每种对映体后，未观察到手性中心的代谢转化。