Schwörer H, Ramadori G
Zentrum Innere Medizin, Abteilung Gastroenterologie und Endokrinologie, Medizinische Universitätsklinik, Göttingen.
Clin Investig. 1993 Aug;71(8):659-62. doi: 10.1007/BF00184497.
Generalized pruritus is a well-known, distressing symptom of various diseases, especially in hepatic cholestasis and chronic renal insufficiency. Its treatment is often unsatisfactory. In three patients with generalized pruritus, intravenous administration of the serotonin type 3 (5-HT3) receptor antagonist ondansetron induced a marked relief of itching. The effect was most pronounced in a patient with cholestasis-associated pruritus. It is suggested that serotonin, acting via 5-HT3 receptors, is involved in the generation and/or sensation of pruritus. Furthermore, 5-HT3 receptor antagonists may be a novel therapeutic principle for the treatment of pruritus.
全身性瘙痒是各种疾病中一种广为人知的、令人苦恼的症状，尤其是在肝内胆汁淤积和慢性肾功能不全时。其治疗往往不尽人意。在三名全身性瘙痒患者中，静脉注射5-羟色胺3（5-HT3）受体拮抗剂昂丹司琼可显著缓解瘙痒。这种效果在一名胆汁淤积相关性瘙痒患者中最为明显。提示5-羟色胺通过5-HT3受体发挥作用，参与瘙痒的产生和/或感觉。此外，5-HT3受体拮抗剂可能是治疗瘙痒的一种新的治疗原则。
