Woźniak H, Wiecek E, Stetkiewicz J, Wyszyńska K
Department of Aerosols, Nofer Institute of Occupational Medicine, Lodz, Poland.
Pol J Occup Med Environ Health. 1993;6(1):55-60.
The aim of this investigation was to quantify the carcinogenic and mutagenic activity of antigorite occurring in the form of admixtures in different mineral raw materials (serpentinite, magnesite, dolomite and nickel ore). The carcinogenicity of dusts was evaluated after intraperitoneal injections of 5 mg (mice) or 20 mg (rats) of dust suspended in saline. A pathomorphological examination was performed in all the dead animals. For two raw materials--serpentinite and nickel ore--their mutagenic potency was investigated (SCE test was used in this study). Results obtained in the experiments on animals (rats and mice) showed that the biological aggressiveness of the mineral raw materials tested was associated with the content of antigorite fibres. Particularly the frequency of mesothelioma (5-85%) was related to the number of antigorite fibres longer than 5 microns. Both of the investigated raw materials (serpentinite and nickel ore) were mutagenic in the SCE test.
本研究的目的是量化以混合物形式存在于不同矿物原料（蛇纹岩、菱镁矿、白云石和镍矿）中的叶蛇纹石的致癌和致突变活性。腹腔注射5毫克（小鼠）或20毫克（大鼠）悬浮于生理盐水中的粉尘后，评估粉尘的致癌性。对所有死亡动物进行病理形态学检查。对于两种原料——蛇纹岩和镍矿——研究了它们的致突变能力（本研究使用姐妹染色单体交换试验）。在动物（大鼠和小鼠）实验中获得的结果表明，所测试矿物原料的生物侵袭性与叶蛇纹石纤维的含量有关。特别是间皮瘤的发生率（5-85%）与长度超过5微米的叶蛇纹石纤维数量有关。所研究的两种原料（蛇纹岩和镍矿）在姐妹染色单体交换试验中均具有致突变性。
