Woźniak H, Wiecek E, Stetkiewicz J, Lao I, Krajnow A, Roszkowicz A
Zakładu Aerozoli Instytutu Medycyny Pracy, Lodzi.
Med Pr. 1992;43(3):257-66.
This work presents the results of the test performed on rats to evaluate the carcinogenic effect of 4 synthetic amphiboles compared to that of the natural amphibole--crocidolite. The dose of the magnesium amphibole (Na2Mg6Si8(OH)2) administered to the animals contained 240 x 10(6) respirable fibres; the corresponding value for the nickel amphibole (Na2Ni6Si8O22(OH)2) was 339 x 10(6), for the cobalt amphibole (Na2Co6Si8O22(OH)2)--1000 x 16(6) for the geranium amphibole (Na2Mg6Ge8(OH)2)--250 x 10(6), and of the natural crocidolite amphibole (Na2Fe2Fe3Si8O22(OH)2) x 380 x 10(6) respirable fibres. The control animals (rats) received physiological NaCl solution. The number of peritoneal mesotheliomas following single intraperitoneal administration of 20 mg of the dust was adapted to be the measure of the carcinogenic activity of the dust. 3 synthetic (magnesium, cobalt and nickel) amphiboles and crocidolite caused development of malignant peritoneal mesothelioma in 11.1% to 71% rats. The results show that there is a relationship between the chemical composition of the synthetic amphiboles and their carcinogenic effect. Out of 4 investigated synthetic amphiboles, the magnesium amphibole, which contained magnesium and silicon, displayed most severe carcinogenic effect. The synthetic amphiboles containing either silicon and cobalt or silicon and nickel displayed 8.3 and 6.2 times weaker ability to induce peritoneal mesothelioma.
本研究展示了对大鼠进行的测试结果，以评估4种合成闪石与天然闪石——青石棉相比的致癌作用。给动物施用的镁闪石（Na2Mg6Si8(OH)2）剂量含有240×10(6)根可吸入纤维；镍闪石（Na2Ni6Si8O22(OH)2）的相应值为339×10(6)，钴闪石（Na2Co6Si8O22(OH)2）为1000×16(6)，锗闪石（Na2Mg6Ge8(OH)2）为250×10(6)，天然青石棉闪石（Na2Fe2Fe3Si8O22(OH)2）为380×10(6)根可吸入纤维。对照动物（大鼠）接受生理氯化钠溶液。单次腹腔注射20毫克粉尘后腹膜间皮瘤的数量被用作衡量粉尘致癌活性的指标。3种合成（镁、钴和镍）闪石和青石棉在11.1%至71%的大鼠中导致恶性腹膜间皮瘤的发生。结果表明，合成闪石的化学成分与其致癌作用之间存在关联。在4种研究的合成闪石中，含有镁和硅的镁闪石显示出最严重的致癌作用。含有硅和钴或硅和镍的合成闪石诱导腹膜间皮瘤的能力分别弱8.3倍和6.2倍。
