Ationu A, Carter N D
Child Health Department, St George's Hospital Medical School, London, England, UK.
Br J Biomed Sci. 1993 Jun;50(2):92-5.
Specific radioimmunoassay techniques were used to measure simultaneously plasma levels of brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) in normal healthy children and adults. The concentrations of BNP in plasma of 20 children (mean +/- SEM; 31 +/- 4 pg/ml) were significantly higher (P < 0.05) than concentrations in plasma of 20 adults (12 +/- 1.8 pg/ml). There was no significant difference in levels of plasma ANP between children (27 +/- 3 pg/ml) and adults (36 +/- 2.2 pg/ml). Plasma levels of BNP were positively correlated with plasma ANP levels in children (r = 0.53, P < 0.02, n = 20) and in adults (r = 0.59, P < 0.02, n = 20). These results suggest that plasma levels of BNP in normal children are higher than levels in normal adults; and provide a useful baseline for comparison with levels of BNP and ANP in plasma of children with impaired cardiac function.
采用特定的放射免疫分析技术，同时测定正常健康儿童和成人血浆中脑钠肽（BNP）和心房钠尿肽（ANP）的水平。20名儿童血浆中BNP的浓度（均值±标准误；31±4 pg/ml）显著高于（P<0.05）20名成人血浆中的浓度（12±1.8 pg/ml）。儿童（27±3 pg/ml）和成人（36±2.2 pg/ml）血浆ANP水平无显著差异。儿童（r = 0.53，P<0.02，n = 20）和成人（r = 0.59，P<0.02，n = 20）血浆BNP水平与血浆ANP水平呈正相关。这些结果表明，正常儿童血浆BNP水平高于正常成人；并为与心功能受损儿童血浆中BNP和ANP水平进行比较提供了有用的基线。
