van der Wiel H E, Lips P, Huijgens P C, Netelenbos J C
Department of Endocrinology, Free University Hospital, Amsterdam, The Netherlands.
Bone Miner. 1993 Jul;22(1):27-32. doi: 10.1016/s0169-6009(08)80078-5.
Heparin therapy may cause osteoporosis. The effects of short-term low-dose heparin are not known. We have studied the effects of short-term heparin administration, twice daily 5000 IU s.c., for 10 days on the biochemical parameters of bone turnover in six healthy male volunteers. No effects were observed on the urinary excretion of hydroxyproline and calcium. Serum levels of cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), a new marker of bone resorption, did not change significantly. A slight but significant decrease in serum alkaline phosphatase was observed. TmP/GFR increased significantly during heparin administration. In all volunteers a uniform increase in serum transaminases appeared which completely reversed after discontinuation of heparin administration. We conclude that short-term low-dose heparin administration does not change biochemical parameters of bone resorption, but has a small significant suppressing effect on serum alkaline phosphatase levels. Heparin administration resulted in a significant but transient increase of serum transaminase levels.
肝素治疗可能会导致骨质疏松症。短期低剂量肝素的作用尚不清楚。我们研究了对六名健康男性志愿者每日两次皮下注射5000国际单位肝素，持续10天的短期给药方式对骨转换生化指标的影响。未观察到对羟脯氨酸和钙的尿排泄有影响。I型胶原交联羧基末端肽（ICTP），一种新的骨吸收标志物，其血清水平未发生显著变化。观察到血清碱性磷酸酶有轻微但显著的下降。在肝素给药期间，TmP/GFR显著增加。所有志愿者的血清转氨酶均出现一致升高，在停用肝素后完全恢复正常。我们得出结论，短期低剂量肝素给药不会改变骨吸收的生化指标，但对血清碱性磷酸酶水平有轻微但显著的抑制作用。肝素给药导致血清转氨酶水平显著但短暂升高。
