Tsorin I B, Kazanova G V, Chichkanov G G
Eksp Klin Farmakol. 1993 May-Jun;56(3):25-7.
In the experiments in rats with myocardial infarction induced by left coronary occlusion, effects of antihypoxants were studied during their long-term intraperitoneal injection (daily once during 21 days) on hemodynamics and myocardial contractility. Sodium oxybutyrate, 200 mg/kg, piracetam, 400 mg/kg, and glyo-6, 100 mg/kg, were shown to exert no significant effects on cardiac contractility at rest, however during exercise they normalized aortic blood flow acceleration. The antihypoxants increased the survival of rats with myocardial infarction.
在通过左冠状动脉闭塞诱导心肌梗死的大鼠实验中，研究了抗缺氧剂在长期腹腔注射（21天内每日一次）期间对血流动力学和心肌收缩力的影响。结果显示，200mg/kg的羟丁酸钠、400mg/kg的吡拉西坦和100mg/kg的glyo-6对静息时的心脏收缩力无显著影响，但在运动期间可使主动脉血流加速恢复正常。这些抗缺氧剂提高了心肌梗死大鼠的存活率。
