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[抗缺氧剂的抗心绞痛作用]

[Anti-anginal action of antihypoxants].

作者信息

Chichkanov G G, Tsorin I B

出版信息

Farmakol Toksikol. 1986 Jan-Feb;49(1):52-6.

PMID:3948988
Abstract

It was shown in experiments on anesthetized cats with modelled acute coronary insufficiency that sodium hydroxybutyrate (200 mg/kg) and in a lesser degree piracetam (400 mg/kg) improve the functional state of the acute myocardial ischemic focus, reduce the rate of growth of creatinephosphokinase activity in coronary sinus blood, increase the retrograde bloodflow to the ischemized zone. Glyo-6 (100 mg/kg) has practically no effect on the investigated indicators.

摘要

在对模拟急性冠状动脉供血不足的麻醉猫进行的实验中发现,羟基丁酸钠(200毫克/千克)以及程度稍轻的吡拉西坦(400毫克/千克)可改善急性心肌缺血灶的功能状态,降低冠状窦血中肌酸磷酸激酶活性的增长速率,增加流向缺血区的逆行血流量。Glyo-6(100毫克/千克)对所研究指标实际上没有影响。

相似文献

1
[Anti-anginal action of antihypoxants].[抗缺氧剂的抗心绞痛作用]
Farmakol Toksikol. 1986 Jan-Feb;49(1):52-6.
2
[The protective action on the myocardium of antihypoxants in acute occlusion and subsequent reperfusion of the coronary artery].[抗缺氧剂对冠状动脉急性闭塞及随后再灌注时心肌的保护作用]
Farmakol Toksikol. 1990 Mar-Apr;53(2):31-4.
3
[Effect of preparations with antihypoxic properties on ischemic damage to the myocardium].[具有抗缺氧特性的制剂对心肌缺血损伤的影响]
Biull Eksp Biol Med. 1986 Nov;102(11):585-7.
4
[Effect of antihypoxic agents on the blood supply and function of the intact and ischemic myocardium].
Farmakol Toksikol. 1985 Mar-Apr;48(2):49-54.
5
[The long-term use of antihypoxants in myocardial infarct in rats: their effect on the hemodynamics and contractile function of the heart].[抗缺氧剂在大鼠心肌梗死中的长期应用:其对心脏血流动力学和收缩功能的影响]
Eksp Klin Farmakol. 1993 May-Jun;56(3):25-7.
6
[The absence of a parallelism between the antihypoxic and anti-ischemic actions of pharmacological agents].[药理制剂抗缺氧作用与抗缺血作用之间缺乏平行关系]
Farmakol Toksikol. 1991 May-Jun;54(3):27-9.
7
[Quantitative assessment of the blood supply to the focus of myocardial ischemia in dogs in pharmacological research].[药理学研究中犬心肌缺血病灶血供的定量评估]
Biull Eksp Biol Med. 1988 Nov;106(11):531-3.
8
[Mechanism of the effect of anti-angina drugs with adrenergic beta receptor agonist action on the collateral hemodynamics and redistribution of the blood flow in chronic myocardial ischemia].[具有肾上腺素能β受体激动作用的抗心绞痛药物对慢性心肌缺血时侧支循环血流动力学及血流再分布的影响机制]
Kardiologiia. 1981 Oct;21(10):85-8.
9
[Effect of sodium oxybutyrate on the blood supply and activity of the normal and ischemic myocardium].[羟丁酸钠对正常及缺血心肌血液供应和活性的影响]
Biull Eksp Biol Med. 1982 Mar;93(3):44-7.
10
[Effect of antianginal agents with a beta-adrenostimulating component of their action on the ischemic myocardium].
Farmakol Toksikol. 1982 Jul-Aug;45(4):37-41.