[The protective action on the myocardium of antihypoxants in acute occlusion and subsequent reperfusion of the coronary artery].

In experiments on anesthetized cats with acute occlusion of the coronary artery followed by its reperfusion antihypoxants piracetam, lithium hydroxybutyrate and pyrid oxynyl-glyoxylate (glyo-6) were shown to stabilize the contractile and pumping functions of the heart. GABA derivatives piracetam and lithium hydroxybutyrate in contrast to glyo-6 were found not only to stimulate the compensatory processes in the conventional intact area of the ischemized left ventricle but also improve the energy metabolism in the ischemic focus itself.