[冠醚衍生物、乙吗噻嗪和艾他西嗪对豚鼠心肌钙池功能的影响]
[The effect of a crown-ether derivative, ethmozine and etatsizin on the functioning of the calcium pools in the guinea pig myocardium].
作者信息
Bogomaz S A, Gurbanov K G, Paperno A A
出版信息
Eksp Klin Farmakol. 1993 May-Jun;56(3):30-2.
PMID:8219986
Abstract
Analysis of the component structure of single contractions of papillary muscles in guinea pigs was used to study the effects of the crown ether derivative benzylase-15-crown-5 and the antiarrhythmic agents ethmozine and ethacizine. The negative inotropic effect of these compounds was shown to be associated with limited penetration of calcium ions from the sarcolemmal pool into cardiac cellular myoplasm.
摘要
通过分析豚鼠乳头肌单收缩的组成结构，研究了冠醚衍生物苄基化-15-冠-5以及抗心律失常药物乙吗噻嗪和乙卡噻嗪的作用。结果表明，这些化合物的负性肌力作用与钙离子从肌膜池向心肌细胞质的有限渗透有关。
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