[The toxic action of the "diabetogenic factor" metabolite in the body during the development of insulin-dependent diabetes].

Investigations of "diabetogenic factor" (DgF) (Diploma No. 386, USSR) in the blood of men and animals with insulin-dependent diabetes have been summarized. The nature and properties of the DgF purified preparation have been outlined and its pathophysiological importance characterized. An inhibitor has been found that inactivate DgF when administered to a diseased individual. It was experimentally established that a single transplantation of cultured healthy beta-cells to an animal with diabetes was successful only in the absence of DgF activity. This leads to stable recover of the animal. The data of other authors have also been briefly discussed.