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[致糖尿病因子及其与肝素复合物的物理化学性质]

[Physicochemical properties of the diabetogenic factor and its complex with heparin].

作者信息

Kudriashov B A, Ammosova Ia M, Liapina L A, Ul'ianov A M

出版信息

Farmakol Toksikol. 1987 May-Jun;50(3):49-52.

PMID:3609278
Abstract

The diabetogenic factor (DGF) isolated from the human blood and the blood of rats with diabetes mellitus was shown to be a protein homogeneous at electrophoresis in gel of polyacrylamide, with the molecular weight of 60,000 D. The interaction of DGF with heparin results in the formation of a complex in which the factor's properties are blocked and those of heparin as a anticoagulant are preserved.

摘要

从人类血液和糖尿病大鼠血液中分离出的致糖尿病因子(DGF)在聚丙烯酰胺凝胶电泳中显示为一种分子量为60,000道尔顿的蛋白质,具有均一性。DGF与肝素相互作用会形成一种复合物,其中该因子的特性被阻断,而肝素作为抗凝剂的特性得以保留。

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1
[Physicochemical properties of the diabetogenic factor and its complex with heparin].[致糖尿病因子及其与肝素复合物的物理化学性质]
Farmakol Toksikol. 1987 May-Jun;50(3):49-52.
2
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Izv Akad Nauk Ser Biol. 1993 Sep-Oct(5):694-702.