Baumgarten E, Wegner R D, Fengler R, Koch H, Henze G
Universitätsklinik Rudolf Virchow, Charlottenburg, Kinderklinik Abt. Hämatologie/Onkologie, Berlin, Germany.
Leuk Lymphoma. 1993 Jun;10(3):237-40. doi: 10.3109/10428199309145889.
A 2 years 4 months old boy with erythroleukemia (FAB-M6) and Down's syndrome is described. Chromosome analysis of bone marrow leukemic blasts revealed apart from the trisomy 21 a partial trisomy of the long arm of chromosome 1:1q23-->1qter in all cells and trisomy 8 mosaicism. To the best of our knowledge this is the first time that a partial trisomy of chromosome 1 in association with erythroleukemia has been described. Previous reports of other hematologic malignancies with aberrations of chromosome 1 indicate that the breakpoint 1q23 is nonrandom and that trisomies of chromosome 1 plays a crucial role in the course of development of hematologic malignancies. This could probably also be true for erythroleukemias.
