Galun E, Ilan Y, Livni N, Ketzinel M, Nahor O, Pizov G, Nagler A, Eid A, Rivkind A, Laster M
Liver Unit, Hadassah University Hospital, Ein-Kerem, Jerusalem, Israel.
Am J Pathol. 1994 Nov;145(5):1001-7.
Hepatitis B virus (HBV) infection and replication have been linked to the development of hepatocellular carcinoma. Bone marrow-derived cells, as well as mesenchymal and epithelial cells, were recently shown to support HBV replication. We hypothesize that the mechanism that links HBV infection and liver tumors might also promote tumor development in tissues permissive for HBV replication. Between 1980 and 1993 we retrospectively identified 22 patients who were hepatitis B surface antigen (HBsAg) carriers and had extra-hepatic malignancies. These patients had 25 tumors, of which 22 were bone marrow derived. HBsAg was detected by immunohistochemistry in bone marrow cells of leukemia patient and of 3 of 10 lymphoma patients. In addition, in 4 of 10 patients with lymphoma, including 2 patients in which HBsAg stained bone marrow cells, HBsAg was also detected in the endothelial cells of blood vessels of the tumor tissue. These results suggest that the identification of an HBV gene product in endothelial cells might point to a role of HBV infection in the development of certain hematopoietic tumors, possibly through activation of cytokines or growth factors, which may eventually lead to bone marrow cell proliferation.
乙型肝炎病毒（HBV）感染与复制已被证实与肝细胞癌的发生有关。最近研究发现，骨髓来源的细胞以及间充质细胞和上皮细胞均支持HBV复制。我们推测，将HBV感染与肝肿瘤联系起来的机制，可能也会在允许HBV复制的组织中促进肿瘤发展。在1980年至1993年期间，我们通过回顾性研究确定了22例乙型肝炎表面抗原（HBsAg）携带者且患有肝外恶性肿瘤的患者。这些患者共有25个肿瘤，其中22个源自骨髓。通过免疫组织化学方法在白血病患者及10例淋巴瘤患者中的3例的骨髓细胞中检测到了HBsAg。此外，在10例淋巴瘤患者中的4例，包括2例HBsAg染色骨髓细胞的患者，在肿瘤组织血管的内皮细胞中也检测到了HBsAg。这些结果表明，在内皮细胞中鉴定出HBV基因产物可能提示HBV感染在某些造血系统肿瘤发生中发挥作用，可能是通过激活细胞因子或生长因子，最终可能导致骨髓细胞增殖。
