Motohashi N, Okamoto Y, Osada M, Yamawaki S
Department of Neurology and Psychiatry, Hiroshima University School of Medicine, Japan.
Neurochem Int. 1993 Oct;23(4):327-30. doi: 10.1016/0197-0186(93)90076-h.
We have examined the effects of swim stress on gamma-aminobutyric acidA (GABAA), GABAB and benzodiazepine (BZD) receptors in synaptic membranes from rat brain. Acute, but not repeated, stress increased the number of BZD receptors in the cerebral cortex. The stress manipulation did not change BZD receptors either in the hippocampus or cerebellum. Furthermore, both GABAA and GABAB receptors did not change in the cerebral cortex, hippocampus or cerebellum after acute and repeated stress. GABA-stimulated BZD binding was not changed following acute or repeated stress. These results suggest that cortical BZD receptors are closely related to responses to acute stress.
我们研究了游泳应激对大鼠脑突触膜中γ-氨基丁酸A（GABAA）、GABAB和苯二氮䓬（BZD）受体的影响。急性应激而非反复应激增加了大脑皮质中BZD受体的数量。应激处理对海马体或小脑中的BZD受体没有影响。此外，急性和反复应激后，大脑皮质、海马体或小脑中的GABAA和GABAB受体均未发生变化。急性或反复应激后，GABA刺激的BZD结合没有改变。这些结果表明，皮质BZD受体与急性应激反应密切相关。
