Smirnov V V, Reznik S R, V'iunitskaia V A, Sorokulova I B, Samgorodskaia N V, Tofan A V
Mikrobiol Z. 1993 Jun-Aug;55(4):92-112.
Data from literature as well as the authors' experimental data on the mechanism of the effect of probiotics from aerobic sporeforming bacteria have been first generalized. The authors made a conclusion that the effect of biopreparations from bacilli is the multifactor process, when bacilli get to the gastrointestinal tract they begin producing biologically active substances which make the immediate effect on pathogenic and conditionally pathogenic microorganisms as well as activate specific and nonspecific systems of the macroorganism protection. The unknown before phenomenon of bacteria translocation is analyzed in detail as one of the most important factors of activation of non-specific resistance of the macroorganisms. Aerobic sporeforming bacteria produce a number of enzymes, amino acids, antibiotic substances and other biologically active substrates which add to the complex treatment-prophylactic effect of biopreparations from these bacteria. Prospects of the use of probiotics based on aerobic sporeforming bacteria in medicine and veterinary are considered. It is emphasized, in particular, that the potential multifactor character of the treatment-prophylactic efficiency of biological preparations from Bacillus is of positive value, since no negative effects are evoked by the known mechanisms of specific effect of aerobic sporeforming bacteria. This opens wide potentialities for improving the schemes and methods of application of probiotics from bacilli, creation of new forms of drugs on their base as well as to combine them with other preparations.
来自文献的数据以及作者关于需氧芽孢杆菌益生菌作用机制的实验数据首次得到了总结。作者得出结论，芽孢杆菌生物制剂的作用是一个多因素过程，当芽孢杆菌进入胃肠道后，它们开始产生生物活性物质，这些物质对致病和条件致病微生物产生直接影响，并激活机体的特异性和非特异性保护系统。细菌易位这一以前未知的现象作为激活机体非特异性抵抗力的最重要因素之一进行了详细分析。需氧芽孢杆菌产生多种酶、氨基酸、抗生素物质和其他生物活性底物，这些都增强了这些细菌生物制剂的综合治疗预防效果。探讨了基于需氧芽孢杆菌的益生菌在医学和兽医学中的应用前景。特别强调的是，芽孢杆菌生物制剂治疗预防效果的潜在多因素特性具有积极意义，因为需氧芽孢杆菌已知的特异性作用机制不会产生负面影响。这为改进芽孢杆菌益生菌的应用方案和方法、基于它们开发新的药物形式以及将它们与其他制剂联合使用开辟了广阔的潜力。
