Kostiuk O P, Chernyshova L I, Volokha A P
Fiziol Zh (1994). 1997;43(3-4):106-15.
The review summarizes experimental and clinical data about the influence of Lactobacillus on the immune system. A conclusion is made that the effect of Lactobacillus is a multifactor process. After entering the intestinal tract live microorganisms or biologically active substances produced by them may activate specific and nonspecific systems of microorganism protection. Experimental and clinical data about the action of Lactobacillus as adjuvants to the humoral immune response are presented. The mechanisms of anticancerogenic action of Lactobacillus and their cell wall components are analyzed in detail. The prospects for the use of Lactobacillus as probiotics in medicine are considered. The conclusion about positive value of the multifactor action of these microorganisms on the human immune system is made, since no negative effects are evoked by the discussed mechanisms of specific effect of Lactobacillus. This opens wide possibilities for the development of application schemes of probiotics from lactobacillus for the stimulation of several functions of the immune system, creation a new forms of antitumor drugs and combination of them with oral vaccines for improving their immunogenicity.
本综述总结了关于乳酸杆菌对免疫系统影响的实验和临床数据。得出的结论是，乳酸杆菌的作用是一个多因素过程。活的微生物或它们产生的生物活性物质进入肠道后，可能会激活微生物保护的特异性和非特异性系统。文中介绍了乳酸杆菌作为体液免疫反应佐剂作用的实验和临床数据。详细分析了乳酸杆菌及其细胞壁成分的抗癌作用机制。探讨了将乳酸杆菌用作医学益生菌的前景。得出了关于这些微生物对人类免疫系统多因素作用的积极价值的结论，因为所讨论的乳酸杆菌特异性作用机制未引发负面影响。这为开发来自乳酸杆菌的益生菌应用方案以刺激免疫系统的多种功能、创造新的抗肿瘤药物形式以及将它们与口服疫苗联合使用以提高其免疫原性开辟了广阔的可能性。
