Wolff S P
Department of Medicine, University College London, UK.
Br Med Bull. 1993 Jul;49(3):642-52. doi: 10.1093/oxfordjournals.bmb.a072637.
Diabetes mellitus is a syndrome initially characterized by a loss of glucose homeostasis. The disease is progressive and is associated with high risk of atherosclerosis, kidney and nerve damage as well as blindness. Abnormalities in the regulation of peroxide and transition metal metabolism are postulated to result in establishment of the disease as well as its longer term complications. Diabetes mellitus is associated with oxidative reactions, particularly those which are catalyzed by decompartmentalized transition metals, but their causative significance in diabetic tissue damage remains to be established.
糖尿病是一种最初以葡萄糖稳态丧失为特征的综合征。该疾病呈进行性发展，与动脉粥样硬化、肾脏和神经损伤以及失明的高风险相关。据推测，过氧化物和过渡金属代谢调节异常会导致该疾病的发生及其长期并发症。糖尿病与氧化反应有关，尤其是那些由非分隔化过渡金属催化的氧化反应，但其在糖尿病组织损伤中的致病意义仍有待确定。
