Kiuchi F, Goto Y, Sugimoto N, Akao N, Kondo K, Tsuda Y
Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
Chem Pharm Bull (Tokyo). 1993 Sep;41(9):1640-3. doi: 10.1248/cpb.41.1640.
A new curcuminoid, cyclocurcumin (IV), was isolated from the nematocidally active fraction of turmeric, the rhizome of Curcuma longa, together with three known curcuminoids, curcumin (I), demethoxycurcumin (II) and bisdemethoxycurcumin (III). The structure of IV was elucidated on the basis of spectral data and confirmed by the partial synthesis from curcumin (I). Although the above curcuminoids were ineffective when they were applied independently, the nematocidal activity increased remarkably when they were mixed, suggesting a synergistic action between them.
从姜黄（Curcuma longa的根茎）具有杀线虫活性的部分中分离出一种新的姜黄素类化合物，环姜黄素（IV），同时还分离出三种已知的姜黄素类化合物，姜黄素（I）、去甲氧基姜黄素（II）和双去甲氧基姜黄素（III）。根据光谱数据阐明了IV的结构，并通过从姜黄素（I）进行部分合成得到证实。尽管上述姜黄素类化合物单独使用时无效，但混合使用时杀线虫活性显著增加，表明它们之间存在协同作用。
