Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Department of General Biology, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
Oxid Med Cell Longev. 2021 Oct 7;2021:9264639. doi: 10.1155/2021/9264639. eCollection 2021.
Exhaustive and acute unusual physical exercise leads to muscle damage. Curcumin has been widely studied due to the variety of its biological activities, attributed to its antioxidant and anti-inflammatory properties. Furthermore, it has shown positive effects on physical exercise practitioners. However, there is no literature consensus on the beneficial effects of curcumin in acute physical activities performed by sedentary individuals. Therefore, we systematically reviewed evidence from clinical trials on the main effects of curcumin supplementation on inflammatory markers, sports performance, and muscle damage during acute physical exercises in these individuals. We searched PubMed/MEDLINE, Scopus, Web of Science, and Embase databases, and only original studies were analyzed according to the PRISMA guidelines. The included studies were limited to supplementation of curcumin during acute exercise. A total of 5 studies were selected. Methodological quality assessments were examined using the SYRCLE's risk-of-bias tool. Most studies have shown positive effects of curcumin supplementation in sedentary individuals undergoing acute physical exercise. Overall, participants supplemented with curcumin showed less muscle damage, reduced inflammation, and better muscle performance. The studies showed heterogeneous data and exhibited methodological limitations; therefore, further research is necessary to ensure curcumin supplementation benefits during acute and high-intensity physical exercises. Additionally, mechanistic and highly controlled studies are required to improve the quality of the evidence and to elucidate other possible mechanisms. This study is registered with Prospero number CRD42021262718.
剧烈且长时间的不寻常体力活动会导致肌肉损伤。姜黄素因其抗氧化和抗炎特性，具有多种生物活性，因此被广泛研究。此外，它对运动者也有积极的影响。然而，关于姜黄素对久坐个体进行急性体力活动的有益作用，目前尚无文献共识。因此，我们系统地综述了临床试验中关于姜黄素补充剂对这些个体在急性体力活动期间炎症标志物、运动表现和肌肉损伤的主要影响的证据。我们检索了 PubMed/MEDLINE、Scopus、Web of Science 和 Embase 数据库，并根据 PRISMA 指南仅分析了原始研究。纳入的研究仅限于姜黄素在急性运动中的补充。共选择了 5 项研究。使用 SYRCLE 的偏倚风险工具评估了方法学质量评估。大多数研究表明，姜黄素补充剂对进行急性体力活动的久坐个体有积极影响。总体而言，补充姜黄素的参与者肌肉损伤较少，炎症减轻，肌肉性能更好。这些研究的数据存在异质性，并表现出方法学上的局限性；因此，需要进一步的研究来确保姜黄素补充剂在急性和高强度体力活动中的益处。此外，需要进行机制和高度控制的研究，以提高证据质量并阐明其他可能的机制。本研究已在 Prospero 注册，编号为 CRD42021262718。
