Wu G
Institute of Basic Medical Sciences, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1993 Jun;15(3):163-7.
In this study, we observed the effects of erythrocytic AHF from normotensive human subjects on heart function of stroke prone SHR (SHRsp) in order to investigate the antihypertensive mechanism of AHF. The results showed that AHF significantly decreased the heart rate (HR), left ventricular end systolic pressure (LVESP), and magnitude of +/- LVdP/dtmax, but had no effect on Wistar Kyoto (WKY) rats, indicating that AHF has negative chronotropic and inotropic action on SHRsp hearts. AHF also lowered the contraction amplitude and resting tension in isolated SHRsp hearts, but had no effect on HR and blood flow of the coronary artery, indicating that AHF exerts negative inotropic action on isolated SHRsp hearts. The results suggest that the antihypertensive mechanism of AHF may be related to its ability to decrease cardiac function in hypertensive rats.
在本研究中，我们观察了正常血压人类受试者的红细胞抗高血压因子（AHF）对易中风自发性高血压大鼠（SHRsp）心脏功能的影响，以探讨AHF的降压机制。结果显示，AHF显著降低了心率（HR）、左心室收缩末期压力（LVESP）以及±LVdP/dtmax的幅度，但对Wistar Kyoto（WKY）大鼠没有影响，这表明AHF对SHRsp心脏具有负性变时性和变力性作用。AHF还降低了离体SHRsp心脏的收缩幅度和静息张力，但对HR和冠状动脉血流量没有影响，这表明AHF对离体SHRsp心脏发挥负性变力性作用。结果提示，AHF的降压机制可能与其降低高血压大鼠心脏功能的能力有关。
