Wu G Y, Wen Y Y, Chen M Q, Zhang S F, Zhou L P
Department of Physiology, Chinese Academy of Medical Sciences, Beijing.
Sheng Li Xue Bao. 1991 Aug;43(4):352-9.
The effects of antihypertensive factor (AHF) from erythrocytes of essential hypertensive human subjects on the systolic blood pressure (SBP) and diastolic blood pressure (DBP) in spontaneously hypertensive rats (SHR), renal hypertensive rats (RHR), Wistar-Kyoto rats (WKY) and Wistar rats were examined. Single intraperitoneal injection of AHF (1.6 mg/kg body weight) resulted in a significant decrease in SBP of SHR and RHR. At 10 min postinjection, AHF lowered the SBP in SHR by 34.0 mmHg. SBP recovered to the original level at 3 h. The maximal decrease of SBP in RHR by 92.5 mmHg was at 24h postadministration and the SBP did not recover until the 9th day. When AHF was administered via femoral vein (0.8 mg/kg body weight), the maximal decrease values of the SBP and the DBP were 42.8 and 48.2 mmHg in SHR at 12 min and 38.3 and 42.5 mmHg in RHR at 25 min postinjection respectively. The DBP in Wistar rats decreased considerably (from 96.7 +/- 12.9 to 83.3 +/- 11.7 mmHg) at 5 min postadministration of AHF, but no effect on DBP in WKY rats was observed. The depressor effect of AHF on SBP in RHR was dose-dependent. AHF could also antagonize the pressor effect of norepinephrine in Wistar rats.
研究了原发性高血压患者红细胞中的降压因子（AHF）对自发性高血压大鼠（SHR）、肾性高血压大鼠（RHR）、Wistar-Kyoto大鼠（WKY）和Wistar大鼠收缩压（SBP）和舒张压（DBP）的影响。单次腹腔注射AHF（1.6mg/kg体重）可使SHR和RHR的SBP显著降低。注射后10分钟，AHF使SHR的SBP降低34.0mmHg。3小时时SBP恢复到原始水平。RHR在给药后24小时SBP最大降低92.5mmHg，直到第9天才恢复。当通过股静脉给药AHF（0.8mg/kg体重）时，SHR在注射后12分钟SBP和DBP的最大降低值分别为42.8和48.2mmHg，RHR在注射后25分钟分别为38.3和42.5mmHg。给药AHF后5分钟，Wistar大鼠的DBP显著降低（从96.7±12.9降至83.3±11.7mmHg），但未观察到对WKY大鼠DBP的影响。AHF对RHR的SBP的降压作用呈剂量依赖性。AHF还可拮抗Wistar大鼠中去甲肾上腺素的升压作用。
