Pirker C, Möslinger T, Wantke F, Götz M, Jarisch R
Dermatologic and Pediatric Allergy Clinic, Vienna, Austria.
Contact Dermatitis. 1993 Sep;29(3):152-4. doi: 10.1111/j.1600-0536.1993.tb03514.x.
The causative agent of thimerosal allergy (sodium ethylmercury thiosalicylate) has not previously been thoroughly investigated. To evaluate whether the organic mercury component or the thiosalicylic acid molecule induces thimerosal sensitization, 23 patients positive to thimerosal were patch tested with ethylmercuric chloride, thiosalicylic acid and 8 different derivatives of mercury. To date, ethylmercuric chloride has not been tested in thimerosal allergy. 19/23 patients (82%) showed positive patch test reactions to ethylmercuric chloride. 4/23 patients negative to ethylmercuric chloride reacted positively to thimerosal 0.1% but not to thimerosal 0.05%. 8/23 patients (35%) also reacted to other mercurials. 20 controls negative to thimerosal showed negative patch test reactions to ethylmercuric chloride. Neither patients nor controls reacted to thiosalicylic acid. These results indicate that testing with thimerosal 0.1% leads to false-positive reactions and that the ethyl mercury component is the responsible agent in thimerosal allergy.
硫柳汞过敏的致病因子（硫柳汞酸钠）此前尚未得到充分研究。为评估有机汞成分或硫代水杨酸分子是否会引发硫柳汞致敏，对23名硫柳汞阳性患者进行了斑贴试验，使用的试剂包括氯化乙基汞、硫代水杨酸以及8种不同的汞衍生物。迄今为止，氯化乙基汞尚未在硫柳汞过敏中进行过测试。19/23名患者（82%）对氯化乙基汞的斑贴试验呈阳性反应。4/23名对氯化乙基汞呈阴性反应的患者对0.1%硫柳汞呈阳性反应，但对0.05%硫柳汞无反应。8/23名患者（35%）对其他汞剂也有反应。20名硫柳汞阴性对照者对氯化乙基汞的斑贴试验呈阴性反应。患者和对照者对硫代水杨酸均无反应。这些结果表明，使用0.1%硫柳汞进行测试会导致假阳性反应，并且乙基汞成分是硫柳汞过敏的致病因素。
