Goncalo M, Figueiredo A, Goncalo S
Clinica de Dermatologia, Hospital da Universidade, Portugal.
Contact Dermatitis. 1996 Mar;34(3):201-3. doi: 10.1111/j.1600-0536.1996.tb02174.x.
There has been increasing interest in characterizing the sensitizing moiety of thimerosal [TIM], following the finding that patients with photosensitivity to piroxicam are allergic to the thiosalicylic acid [TIO] moiety of TIM. For this purpose, the authors have conducted 2 studies in TIM-sensitive patients. In the 1st, of 175 patients tested with TIO and ammoniated mercuric chloride [HGAM], 45.7% reacted only to TIM, whereas 45.7% reacted also to TIO and 17.7% also to HGAM; 9.1% reacted to both TIO and HGAM. In the 2nd, of 47 patients tested with TIO and ethylmercuric chloride [ETHG], 87.2% reacted to ETHG, 44.7% to TIO and 31.9% reacted to both. None of the patients reacted only to TIM. The authors conclude that thimerosal allergy is due either to the mercuric moiety or to thiosalicylic acid, with no cases of sensitivity only to the whole molecule of TIM. TIM-sensitive patients are mainly allergic to the mercuric moiety, but among them there are a large number of TIO-sensitive patients, and these should be advised to avoid piroxicam.
自从发现对吡罗昔康光敏的患者对硫柳汞（TIM）的硫代水杨酸（TIO）部分过敏后，人们对确定硫柳汞的致敏部分越来越感兴趣。为此，作者对硫柳汞敏感的患者进行了两项研究。在第一项研究中，175名接受硫代水杨酸和氯化氨汞（HGAM）检测的患者中，45.7%仅对硫柳汞有反应，而45.7%对硫代水杨酸也有反应，17.7%对氯化氨汞也有反应；9.1%对硫代水杨酸和氯化氨汞都有反应。在第二项研究中，47名接受硫代水杨酸和氯化乙基汞（ETHG）检测的患者中，87.2%对氯化乙基汞有反应，44.7%对硫代水杨酸有反应，31.9%对两者都有反应。没有患者仅对硫柳汞有反应。作者得出结论，硫柳汞过敏要么是由于汞部分，要么是由于硫代水杨酸，不存在仅对硫柳汞整个分子敏感的情况。硫柳汞敏感的患者主要对汞部分过敏，但其中有大量对硫代水杨酸敏感的患者，应该建议这些患者避免使用吡罗昔康。
