Hellsten G, Boman K, Saarem K, Hallmans G, Nilsson T K
Primary Health Care Centre, Norsjö, Sweden.
Curr Med Res Opin. 1993;13(3):133-9. doi: 10.1185/03007999309111542.
In addition to their beneficial effects in reducing platelet responsiveness, it has been a matter of controversy whether polyunsaturated fatty acids impair the fibrinolytic system or not. In a double-blind, parallel clinical trial, 40 subjects were randomized to treatment with 6 g/day of corn oil, or to 6 g/day of a fish oil preparation, enriched with omega-3-polyunsaturated fatty acids (2.0 g/day of omega-3-PUFA). Clinical and fibrinolytic variables were measured before and after 5 months of treatment. In the corn oil group, plasminogen activator inhibitor (PAI-1) decreased significantly but in the cod liver oil group, PAI-1 remained unchanged. Activities and mass concentrations of tissue plasminogen activator (t-PA) were unchanged in both groups. It is concluded that, in the doses given here, both these preparations have small or no effects on the fibrinolytic system.
除了在降低血小板反应性方面具有有益作用外，多不饱和脂肪酸是否会损害纤维蛋白溶解系统一直存在争议。在一项双盲、平行临床试验中，40名受试者被随机分为两组，一组每天服用6克玉米油，另一组每天服用6克富含ω-3多不饱和脂肪酸（每天2.0克ω-3多不饱和脂肪酸）的鱼油制剂。在治疗5个月前后测量临床和纤维蛋白溶解变量。玉米油组中，纤溶酶原激活物抑制剂（PAI-1）显著降低，但在鱼肝油组中，PAI-1保持不变。两组中组织纤溶酶原激活物（t-PA）的活性和质量浓度均未改变。得出的结论是，在此处给予的剂量下，这两种制剂对纤维蛋白溶解系统的影响很小或没有影响。
