用于基因组应用的数字化且具有差异阴影的人类染色体 ideogram。

Digitized and differentially shaded human chromosome ideograms for genomic applications.

作者信息

Francke U

机构信息

Department of Genetics, Stanford University Medical Center, CA 94035-5428.

出版信息

Cytogenet Cell Genet. 1994;65(3):206-18. doi: 10.1159/000133633.

DOI:10.1159/000133633

PMID:8222762

Abstract

Human chromosome ideograms that depict 850 bands, numbered in agreement with ISCN (1981) nomenclature but based on actual measurements of band sizes and differentiated by five shades of staining intensity, have been digitized using commercially available graphics software. They provide for more accurate estimates of distances within chromosome arms, DNA content of chromosome bands and correlation between cytogenetic, molecular and genetic linkage maps than the standard ISCN ideograms.

摘要

描绘850条带的人类染色体 ideogram，其编号与ISCN（1981）命名法一致，但基于带大小的实际测量，并通过五种染色强度阴影进行区分，已使用商用图形软件进行数字化处理。与标准的ISCN ideogram相比，它们能更准确地估计染色体臂内的距离、染色体带的DNA含量以及细胞遗传学、分子和遗传连锁图谱之间的相关性。