Zhu X X, Zhou X P, Zhong X L, Zhong C S, Yu Y F
Diabetes Research Department, Hua Shan Hospital, Shanghai Medical University.
Chin Med J (Engl). 1993 Jun;106(6):463-6.
Microscopic quantitative cardiomyopathy was previously reported in spontaneous diabetic biobreeding (BB) rats, but the nature of the lesions remains obscure. To further study the specificity of cardiomyopathy in streptozotocin-diabetic rats and discuss the existence of diabetic heart disease, we compared 40 streptozotocin-diabetic rats (D group) with 40 normal control rats (C group) at various durations in plasma glucose, fructosamine, plasma lipid, left ventricular enzyme contents and alterations of myocardial cells and coronary artery tree under electron and light microscope respectively. In 4 weeks, D rats showed myocardial mitochondrial swelling and degeneration, whereas at 8 weeks, myocardial enzyme contents markedly decreased, and myocardial lesions were more conspicuous with disruption of myocardial cells, formation of myocardial contraction bands, dilatation of intercalated discs, deposition of glycogen granules, etc. At 11 weeks, microscopic changes were essentially similar, whereas the decrease of enzyme contents became more conspicuous. During the 11 weeks, persistent and marked hyperglycemia and elevation of fructosamine were observed, however, no abnormalities were found along the coronary artery tree in the D rats. The results indicated that cardiomyopathy is diabetes specific, and exists independently as one of the three important components of diabetic heart disease.
先前有报道称，在自发性糖尿病生物繁殖（BB）大鼠中存在微观定量性心肌病，但病变的本质仍不清楚。为了进一步研究链脲佐菌素诱导的糖尿病大鼠心肌病的特异性，并探讨糖尿病性心脏病的存在情况，我们分别在不同时间点，将40只链脲佐菌素诱导的糖尿病大鼠（D组）与40只正常对照大鼠（C组）在血糖、果糖胺、血脂、左心室酶含量以及电子显微镜和光学显微镜下心肌细胞和冠状动脉树的变化等方面进行了比较。在4周时，D组大鼠出现心肌线粒体肿胀和变性，而在8周时，心肌酶含量显著降低，心肌病变更加明显，出现心肌细胞破裂、心肌收缩带形成、闰盘扩张、糖原颗粒沉积等。在11周时，微观变化基本相似，然而酶含量的降低变得更加明显。在这11周期间，观察到D组大鼠持续且显著的高血糖和果糖胺升高，但是在D组大鼠的冠状动脉树中未发现异常。结果表明，心肌病具有糖尿病特异性，并且作为糖尿病性心脏病的三个重要组成部分之一独立存在。
