Zhou X D, Mao T Q
Stomatological college, Fourth Military Medical University, Xi'an.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1993 Jan;28(1):15-6, 63.
Tca 8113 (human tongue cancer cell line) cell transplanted tumors in nude mice were treated with cryosurgery for three freeze-thaw cycles. Tumor samples were obtained by biopsies pre- and post-cryosurgery for morphological study. The results showed intercellular adhesion damage, nuclear pyknosis, cell death, etc. One week after, the deep parts of the frozen samples were similar to that of the untreated ones. Our study indicates the change of biomembrance may be also important as of nuclei in cell death and may play an important role in the treatment of cancer by cryochemistry.
将人舌癌细胞系Tca 8113细胞移植到裸鼠体内形成的肿瘤，采用冷冻手术进行三个冻融循环治疗。在冷冻手术前后通过活检获取肿瘤样本用于形态学研究。结果显示细胞间黏附损伤、核固缩、细胞死亡等。一周后，冷冻样本深部与未处理样本相似。我们的研究表明，生物膜的变化在细胞死亡中可能与细胞核变化同样重要，并且在冷冻化学治疗癌症中可能发挥重要作用。
