Zeng W Z, Chu R J, Jiang M D
First Department of Internal Medicine, General Hospital of Chengdu Army.
Zhonghua Nei Ke Za Zhi. 1993 Mar;32(3):167-9.
11 kinds of HBV, HCV and HDV serum markers were investigated in 46 patients with HCC, 48 patients with LC, and 52 controls without liver disease. The prevalence of one out of HBV or HCV or HDV markers (M) in HCC and LC was 91.3% and 95.8% respectively, significantly higher than that in controls (17.3%). Positivity of HBV-M in HCC and LC was remarkably higher than those of HCV-M and HDV-M (P < 0.05). Prevalence of HCV-M in HBV-M negative HCC and LC was 66.7% and 75.0% respectively, significantly higher than that in HBV-M positive cases (P < 0.05). Frequency of viral replication in HCC and LC was significantly higher than that in controls (P < 0.01). The co-occurrence of two or three kinds of viral markers in HCC was more prevalent than that in LC (38% vs 14%, P < 0.05). Patients with coinfection from both HBV and HDV had a significantly younger age than those infected by HBV alone or infected by HCV (more than 10 years earlier). Among HCC and LC, 36% of HBV seronegative cases had HBV DNA detectable in their serum. Our data suggest that HCC and LC have a close association with the infection of HBV HCV and HDV especially HBV. Active viral replication and coinfection of several kinds of virus play on important role in the determination of HCC or LC development, and HDV appears to provide an additional risk for HCC and LC. In HBV-M negative cases, HCV infection may be more important for HCC and LC development than HBV.
对46例肝癌患者、48例肝硬化患者和52例无肝病的对照者检测了11种乙肝病毒（HBV）、丙肝病毒（HCV）和丁肝病毒（HDV）血清标志物。肝癌和肝硬化患者中HBV、HCV或HDV标志物（M）单项阳性率分别为91.3%和95.8%，显著高于对照组（17.3%）。肝癌和肝硬化患者中HBV-M阳性率显著高于HCV-M和HDV-M（P<0.05）。HBV-M阴性的肝癌和肝硬化患者中HCV-M阳性率分别为66.7%和75.0%，显著高于HBV-M阳性患者（P<0.05）。肝癌和肝硬化患者的病毒复制频率显著高于对照组（P<0.01）。肝癌患者中两种或三种病毒标志物同时出现的情况比肝硬化患者更常见（38%比14%，P<0.05）。同时感染HBV和HDV的患者年龄显著小于单独感染HBV或HCV的患者（早10年以上）。在肝癌和肝硬化患者中，36%的HBV血清学阴性病例血清中可检测到HBV DNA。我们的数据表明，肝癌和肝硬化与HBV、HCV和HDV感染密切相关，尤其是HBV。病毒的活跃复制和多种病毒的合并感染在肝癌或肝硬化的发生发展中起重要作用，HDV似乎增加了肝癌和肝硬化的发病风险。在HBV-M阴性病例中，HCV感染对肝癌和肝硬化发生发展的作用可能比HBV更重要。
